CHRONIC VARIABLE STRESS AFFECTS HIPPOCAMPAL NEUROTROPHIC FACTOR GENE EXPRESSION IN THE NOVELTY-SEEKING PHENOTYPE: EPIGENETIC REGULATION by
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Author: Ozge Oztan Title: Chronic Variable Stress Affects Hippocampal Neurotrophic Factor Gene Expression in the Novelty-Seeking Phenotype: Epigenetic Regulation Institution: Florida Atlantic University Thesis Advisor: Dr. Ceylan Isgor Degree: Master of Science Year: 2009 Experimentally naïve rats exhibit varying degrees of novelty exploration. Some rats display high rates of locomotor reactivity to novelty (high responders; HR), and others display low rates (low responders; LR). The novelty-seeking phenotype (LRHR) is introduced as a model of stress responsiveness. In this thesis I examined effects of chronic variable physical and social stress or control handling on the levels of various neurotrophins in the hippocampus, and changes in mossy fibre terminal fields in LRHR rats. A positive correlation is seen between histone deacetylase 2 and brain-derived neurotrophic factor (BDNF) levels both of which are oppositely regulated in LRHR CA3 fields in response to chronic social stress. Increase in BDNF levels in CA3 field accompanied increase in supra-pyramidal mossy fibre terminal field size (SP-MF) in HRs, and decrease in
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Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression.
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